2025年12月，中国工业与应用数学学会新期刊《CSIAM Transactions on Life Sciences》（CSIAM-LS）上线发行2025年第四期。

CSIAM-LS是由中国工业与应用数学学会（CSIAM）继旗舰期刊《CSIAM Transactions on Applied Mathematics》后推出的一本新期刊，是学会CSIAM Transactions系列的第一个子刊。由中国工业与应用数学学会和香港GLOBAL SCIENCE PRESS出版社合作出版，为英文季刊，每年的3月、6月、9月、12月出版。

CSIAM-LS是一本创新性的跨学科期刊，聚焦数学与生命科学的交叉领域，覆盖生物学和医学的数学理论、模型和算法，包括计算系统生物学、生物信息学、生物医学工程、群体动力学、计算神经科学等。旨在推动传统数学生命科学的发展，开拓新兴方向，促进学科交叉与融合。

该期刊由中国工业与应用数学学会前任理事长、中国科学院院士、武汉大学校长张平文担任主编，上海交通大学数学科学学院讲席教授楼元担任总编辑，拥有一支顶尖学者组成的编辑委员会，包含美国国家科学院院士、英国皇家学会会士等63位数学生命科学领域的国内外知名学者。

期刊2025年第四期共7篇文章，论文目录、摘要及作者信息如下：

Wenxu Ning, Jie Lou, Litao Han, Sanling Yuan

Invasion Dynamics of Alien Mussels: A Mussel-Algae Model with Time Delay in Filter Feeding and Environmental Variability

摘要：The dynamic behavior of alien mussels interacting with algae after arriving in a new environment has long been a focus of invasion ecology research. This paper extends and analyzes a classical mussel-algae model by incorporating a time delay in mussel filter feeding and accounting for environmental variability. We theoretically study the stochastic dynamics, including the global existence and uniqueness of the positive solution, the existence of a unique stationary distribution, and mussel extinction, using tools from stochastic analysis. Furthermore, we derive an explicit expression for the probability density function around the quasi-stable equilibrium by solving the corresponding Fokker-Planck equation. Our theoretical and numerical results indicate that: (a) larger environmental disturbances or artificial removal can effectively prevent the survival of alien mussels in novel habitats, (b) a decreased filter feeding rate leads to an accelerated extinction rate of mussels, and (c) an increased consumption constant c decelerates the transition rate of mussels from the initial state to the extinction state, as analyzed through the mean first passage time of mussels. These findings highlight the complex interaction between intrinsic and extrinsic factors in influencing the invasion dynamics of alien mussels.

Ye Zheng, Junyuan Yang, Xuezhi Li

Dynamics and Optimal Control of a Size-Structured Influenza Model Linking Within-Host and Between-Host

摘要：Multi-scale models improve the prediction of key epidemic factors and disease prevalence by capturing the interaction between individual immune responses and the spread of diseases among the population, helping to implement targeted control strategies for disease management. In this paper, we develop a novel size-structured influenza model based on the nested rules, aiming to explore how the replication of influenza virus affects its transmission at a population level. We calculate the basic reproduction numbers separately at the individual and population levels and rigorously prove the conditions under which the feasible equilibrium exists and is stable. Then, by evaluating the effectiveness of four measures consisting of individual antiviral treatment and population vaccination, we can determine an optimal treatment to minimize both the influenza cases and the total expenditure on influenza prevention. Numerical results reveal the complex interactions between the two interventions and the progression of the epidemic.

Yiping Tan, Suli Liu, Yongli Cai, Xiaodan Sun, Zhihang Peng, Weiming Wang

Stochastic Dynamics Between HIV-1 Latent Infection and cART Efficacy Within the Brain Microenvironment

摘要：We develop a stochastic human immunodeficiency virus type 1 (HIV-1) infection model to analyze combination antiretroviral therapy (cART) dynamics in the brain microenvironment, explicitly accounting for two infected cell states: (1) productively infected and (2) latently infected populations. The model introduces two key epidemiological thresholds (productive infection) and (latent infection) -- and defines the stochastic control reproduction number as . Our analysis reveals three distinct dynamical regimes: (1) viral extinctionthe infection clears exponentially with probability one; (2) latent reservoir dominance the system almost surely converges to a purely latent state, characterizing stable viral reservoir formation; (3) persistent productive infection the infection persists indefinitely with a unique stationary distribution, for which we derive the exact probability density function. And numerical simulations validate these theoretical predictions, demonstrating how environmental noise critically modulates HIV-1 dynamics in neural reservoirs. Our results quantify the stochastic balance between productive infection, latency establishment, and cART efficacy, offering mechanistic insights into viral persistence in the brain.

Xin Zhao, Na Tian, Shiyang Yu, Meng Fan

Dynamics of Coral-Algae Phase Shifts via Ecological Stoichiometric Approach

摘要：Coral reefs have evolved over hundreds of millions of years and are now considered one of the most critical yet vulnerable ecosystem on earth. Environmental changes, including variations in light availability, nutrient levels, and fishing pressure, can significantly impact the health of coral reefs, potentially leading to ecosystem degradation. A coral-macroalgae-herbivorous fish model is developed based on ecological stoichiometry to investigate the dynamics of coral-algae phase shifts. The positivity, invariance, and dissipativity of the model are carefully established, the existence and stability of equilibria are rigorously demonstrated, and rich dynamics such as bistability and various types of periodic oscillations are numerically explored. Furthermore, the effects of environmental factors (e.g., light intensity, nutrient levels, and fishing pressure) on the system’s dynamics are investigated. The main findings highlight that environmental variations are key drivers of ecological phase transitions in coral reef ecosystems, providing more insights into the mechanisms underlying coral-algae dynamics and offering implications for the sustainable management of coral reefs.

Yueping Dong, Tianyu Gao, Jun Zhang, Yasuhiro Takeuchi

Exploring the Impact of Media Coverage and Limited Medical Resources on Influenza Transmission Dynamics: Insights from a Mathematical Modeling Study

摘要：Changes in personal protective behaviors driven by media influence contribute to epidemic prevention and control, whereas limited medical resources constrain the effectiveness of such interventions. In this study, we propose a novel influenza transmission model with the media impact and limited medical resources. Theoretical and numerical analyses reveal some complex nonlinear dynamics, including saddle node bifurcations, forward and backward bifurcations, and both subcritical and supercritical Hopf bifurcations. Besides, two types of bistable scenarios are identified: bistability of a disease-free equilibrium and an endemic equilibrium, and bistability of two different endemic equilibria. In addition, we fit the model to the monthly new influenza reported case data from August 2023 to October 2024 in Jiangsu, China, where the fitting results successfully capture the observed epidemic trends. The estimated basic reproduction numberimplies sustained transmission. Finally, sensitivity analysis suggests that effectively controlling influenza transmission can be achieved by decreasing the population input rate, transmission rate, awareness loss rate, and medical saturation constant, as well as increasing the awareness transmission rate, media response intensity, and maximum recovery rate. These findings highlight the critical role of combining public awareness initiatives with enhanced medical resource allocation to strengthen influenza prevention and control efforts.

Bruno Buonomo, Emanuela Penitente

A Two-Patch Epidemic Model with Prevalence-Dependent Contact Patterns and Migration Rates

摘要：We consider a two-patch Susceptible-Infected-Recovered epidemic model that incorporates awareness-driven behavioural changes in both contact and mobility patterns. Individuals modify their behaviour in response to a perceived risk of infection, which is modelled through two awareness variables that depend either on the current or past disease prevalence in each patch. We qualitatively analyse the model through stability and bifurcation theory and derive threshold conditions that determine the existence and stability of the biologically relevant equilibria. We find that awareness-induced behavioural changes in contact and mobility can destabilise mixed equilibria–where the disease persists in one patch only–and contribute to the emergence of stable co-endemic states. When awareness depends on past epidemic values, the stability analysis shows that mixed equilibria may lose stability via Hopf bifurcations, depending on the sign of some awareness-related parameters. Finally, the impact of the behaviour-related parameters on the epidemic dynamics is investigated through numerical simulations.

Siyu Kang, Xue Rui, Huarong Ren

A Brucellosis Model with Different Clinical Symptoms and a Time Delay Representing Incubation Period: Global Dynamics and Data Fitting

摘要：Brucellosis is a significant zoonotic disease that has a high incidence rate in sheep, particularly in the Inner Mongolia region of China. To better investigate its transmission dynamics, this paper proposes a sheep brucellosis model incorporating acute and chronic infections, a saturated incidence rate describing environmental transmission and a time delay representing the incubation period. By constructing LyapunA Brucellosis Model with Different Clinical Symptoms and a Time Delay Representing Incubation Period: Global Dynamics and Data Fittingov functionals and using LaSalle’s invariance principle, it is shown that the global dynamics of the disease is completely determined by the basic reproduction number: If the brucellosis always dies out; if , a unique endemic equilibrium exists and is globally asymptotically stable. Using data of sheep brucellosis cases in Inner Mongolia from 2016 to 2020, unknown parameters and the basic reproduction numberare estimated via the Markov chain Monte Carlo method. Numerical simulations show that reducing the transmission rate of acutely infected sheep while increasing the culling rate of symptomatic infected sheep is the most effective strategy to control the spread of brucellosis in Inner Mongolia. Notably, decreasing the proportion of acutely infected sheep or increasing acute-to-chronic conversion rate may lead to a significant short-term increase in chronically infected sheep.

期刊官网：https://global-sci.com/index.php/csiam-ls/index

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